DNA Binding Motif

Accessions: 6fqp_B (3D-footprint 20231221)
Names: Homeobox protein TGIF1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of TALE homeobox domain transcription factor TGIF1 with its consensus DNA
Length: 6
Consensus: ctGTCA
01 13 57 13 13 c
02 16 13 13 54 t
03 0 0 96 0 G
04 0 0 0 96 T
05 0 96 0 0 C
06 96 0 0 0 A
Binding TFs: 6fqp_B (Homeobox domain, Homeobox KN domain)
Binding Sites: 6fqp_L / 6fqp_M
Publications: Guca E, Suñol D, Ruiz L, Konkol A, Cordero J, Torner C, Aragon E, Martin-Malpartida P, Riera A, Macias MJ. TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling. Nucleic Acids Res 46:9220-9235 (2018). [Pubmed]

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