DNA Binding Motif

						

			
Accessions: NFIC_2 (HT-SELEX2 May2017), MA1527.1 (JASPAR 2024)

			
Names: NFIC, NFIC(var.2)
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 17
Consensus: sTTGGCrysgTGCCArs
Weblogo: 
PSSM: P0      A      C      G      T
01    398    560    761    399      s
02    167    616     65   2118      T
03      0      0      5   2118      T
04      0      0   2118      0      G
05      0      3   2118      0      G
06    100   2118      0      0      C
07    696    268    694    461      r
08    389    705    492    531      y
09    443    580    678    417      s
10    476    382    881    379      g
11    203    340     97   2118      T
12      0      0   2118      0      G
13      0   2118     13      0      C
14      3   2118      0      0      C
15   2118      0      0      0      A
16   1086     19   1032    154      r
17    364    695    647    412      s
Type: Heterodimer
Binding TFs: P08651 (CTF/NF-I family transcription modulation region, MH1 domain, Nuclear factor I protein pre-N-terminus)
NFIC (CTF/NF-I family transcription modulation region, MH1 domain, Nuclear factor I protein pre-N-terminus)
P08651
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Heng YH, Barry G, Richards LJ, Piper M. Nuclear factor I genes regulate neuronal migration. Neurosignals : (2012;20(3):159-67.). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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