DNA Binding Motif

						

			
Accessions: BHLHA15_4 (HT-SELEX2 May2017), MA1472.1 (JASPAR 2024)

			
Names: BHLHA15, BHLHA15(var.2)
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 10
Consensus: avCAGCTGyy
Weblogo: 
PSSM: P0      A      C      G      T
01    697    281    357    170      a
02    897    607    591     81      v
03     47   1504      6     33      C
04   1504     33     33    137      A
05     11     30   1504    467      G
06    445   1504     72     11      C
07     54      4      0   1504      T
08      0      0   1504      0      G
09     54    610    489   1015      y
10    202    410    316    577      y
Type: Heterodimer
Binding TFs: BHLHA15 (Helix-loop-helix DNA-binding domain)
Q7RTS1 (Helix-loop-helix DNA-binding domain)
Q7RTS1
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Lo HG, Jin RU, Sibbel G, Liu D, Karki A, Joens MS, Madison BB, Zhang B, Blanc V, Fitzpatrick JA, Davidson NO, Konieczny SF, Mills JC. A single transcription factor is sufficient to induce and maintain secretory cell architecture. Genes Dev 31:154-171 (2017). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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