DNA Binding Motif

						

			
Accessions: SREBF2_DBD (HumanTF 1.0), MA0828.1 (JASPAR 2024)

			
Names: SREBF2, SREBF2(var.2)
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 10
Consensus: ATCACGTGAy
Weblogo: 
PSSM: P0      A      C      G      T
01   2898    284   1059     13      A
02    385    130     16   3957      T
03      7   3957     16      1      C
04   3957      2     75     12      A
05      3   3957     82     11      C
06     21    341   3957      0      G
07     44    240      0   3957      T
08      3     13   3957      8      G
09   3957      8     39    122      A
10     20   2114    104   1843      y
Type: Heterodimer
Binding TFs: SREBF2_DBD (Helix-loop-helix DNA-binding domain)
Q12772 (Helix-loop-helix DNA-binding domain)
Q12772
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Shimano H. Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog Lipid Res 40:439-52 (2001). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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