DNA Binding Motif

						

			
Accessions: GLI3_2 (HT-SELEX2 May2017), MA1491.1 (JASPAR 2024)

			
Names: GLI3
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 15
Consensus: vGACCACCCACgwcG
Weblogo: 
PSSM: P0      A      C      G      T
01   9265   7913   7702   2622      v
02    177    232  18754   1323      G
03  17348   3972   2832      3      A
04     68  19263      7      0      C
05      7  19329      1      0      C
06  18184   2211    194    699      A
07      3  19326      4      1      C
08   4984  18084      1      2      C
09    528  18879     15    323      C
10  18709      0   1486      0      A
11   2186  17927   1360   1506      C
12   4643   5419  12721   1615      g
13   8397   3326   5324   9056      w
14   6506  11363   2363   6602      c
15    953   2625  17621   1731      G
Type: Heterodimer
Binding TFs: P10071 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
GLI3 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
P10071
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Kinzler K. W., Vogelstein B. The GLI Gene Encodes a Nuclear Protein Which Binds Specific Sequences in the Human Genome. Mol. Cell. Biol. 10:634-642 (1990). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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