DNA Binding Motif

Accessions: HOXA1_3 (HT-SELEX2 May2017), MA1495.1 (JASPAR 2024)
Names: HOXA1
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 8
Consensus: sTAATtAs
Weblogo:
PSSM: P0 A C G T
01 1167 2244 2667 1328 s
02 0 1546 0 7406 T
03 7406 2083 1244 0 A
04 7406 0 0 0 A
05 0 0 0 7406 T
06 0 1310 2265 7406 t
07 7406 0 1576 0 A
08 1175 2811 2237 1182 s
Type: Heterodimer
Binding TFs: P49639 (Homeobox domain)
HOXA1 (Homeobox domain)
P49639
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

Pearson JC, Lemons D, McGinnis W. Modulating Hox gene functions during animal body patterning. Nat Rev Genet 6:893-904 (2005). [Pubmed]

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