DNA Binding Motif

						

			
Accessions: 6xwg_CD (3D-footprint 20231221)

			
Names: Retinoic acid receptor RXR-alpha
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of the Human RXR/RAR DNA-Binding Domain Heterodimer Bound to the Human RARb2 DR5 Response Element
Length: 16
Consensus: GTTCAnnnnnaGTTcA
Weblogo: 
PSSM: P0      A      C      G      T
01      6      6     78      6      G
02      0      0      0     96      T
03      0      0      0     96      T
04      0     96      0      0      C
05     96      0      0      0      A
06     24     24     24     24      n
07     24     24     24     24      n
08     24     24     24     24      n
09     24     24     24     24      n
10     24     24     24     24      n
11     64     14     12      6      a
12      0      0     96      0      G
13      0      0      0     96      T
14      6      8      6     76      T
15     12     57     15     12      c
16     96      0      0      0      A
Type: Heterodimer
Binding TFs: 6xwg_C (Zinc finger, C4 type (two domains))
6xwg_D (Zinc finger, C4 type (two domains))
Binding Sites: 6xwg_A
6xwg_B
			
Publications: Osz J, McEwen AG, Bourguet M, Przybilla F, Peluso-Iltis C, Poussin-Courmontagne P, Mély Y, Cianférani S, Jeffries CM, Svergun DI, Rochel N. Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR-RXR. Nucleic Acids Res 48:9969-9985 (2020). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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