DNA Binding Motif

						

			
Accessions: ERF_NHLH1 (HumanTF2 1.0), MA1938.1 (JASPAR 2024)

			
Names: ERF_NHLH1, ERF::NHLH1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 17
Consensus: aGCAGCTGCCGGAWrym
Weblogo: 
PSSM: P0      A      C      G      T
01    156     81     81      7      a
02      0     14    290     21      G
03      5    317     14     18      C
04    324      0      0      0      A
05      1     11    288     28      G
06     26    301      2      8      C
07     10     20     13    324      T
08      1     12    317     15      G
09      0    316      6      8      C
10     12    327     11      1      C
11     27      0    325      7      G
12      4     10    313     26      G
13    324     21      3     12      A
14    241      0     11     84      W
15    113      3    176     40      r
16      0    108     16    210      y
17    105     82     74     65      m
Type: Heterodimer
Binding TFs: Q02575 (Helix-loop-helix DNA-binding domain)
NHLH1_TF2 (Helix-loop-helix DNA-binding domain)
ERF_TF1 (Ets-domain)
Q02575
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]


Dang W, Sun XH, Sen R. ETS-mediated cooperation between basic helix-loop-helix motifs of the immunoglobulin mu heavy-chain gene enhancer. Mol Cell Biol 18:1477-88 (1998). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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