DNA Binding Motif

						

			
Accessions: THRB_8 (HT-SELEX2 May2017), MA1576.1 (JASPAR 2024)

			
Names: THRB, THRB(var.3)
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 19
Consensus: rTGACCTyacrTGACCTyA
Weblogo: 
PSSM: P0      A      C      G      T
01    119     31    157     82      r
02      0      8      0    381      T
03     28     89    389     45      G
04    389     19     17     71      A
05      0    389      4     17      C
06      0    389     59     20      C
07     13     75     38    389      T
08     11    134     93    151      y
09    263     28     89      9      a
10     42    221     71     54      c
11    102     86    205      0      r
12      0      0      6    393      T
13      0      0    389      3      G
14    389     11      0     86      A
15      0    389      0      2      C
16      7    389      3      4      C
17      0      9      0    389      T
18      0    175     73    214      y
19    323      8     74      0      A
Type: Heterodimer
Binding TFs: P10828 (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains))
THRB (Zinc finger, C4 type (two domains))
P10828
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Lu C, Cheng SY. Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors. J Mol Endocrinol 44:143-54 (2010). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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