DNA Binding Motif

						

			
Accessions: CLOCK_EVX1_1 (HumanTF2 1.0)

			
Names: CLOCK_EVX1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 17
Consensus: rTaATyayygmCACGTG
Weblogo: 
PSSM: P0      A      C      G      T
01    850    101    368    139      r
02      2     51      0    850      T
03    558    196    291    191      a
04    850     24      2     12      A
05     36     96     70    850      T
06     10    522    230    328      y
07    850     43    282    254      a
08      5    434    133    277      y
09    164    341    132    213      y
10     92    208    390    159      g
11    446    277    122      4      m
12     54    850      0      2      C
13    850      0    239      7      A
14      0    850      1    226      C
15    260      2    850      0      G
16     12    154     16    850      T
17      7      0    850     37      G
Type: Heterodimer
Binding TFs: CLOCK_TF1 / CLOCK_TF2 (Helix-loop-helix DNA-binding domain)
EVX1_TF1 / EVX1_TF2 (Homeobox domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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