DNA Binding Motif

						

			
Accessions: 3d1n_IK (3D-footprint 20231221)

			
Names: POU domain, class 6, transcription factor 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of human Brn-5 transcription factor in complex with corticotrophin-releasing hormone gene promoter
Length: 22
Consensus: ATATnnTATAnnyATAntTTAT
Weblogo: 
PSSM: P0      A      C      G      T
01     90      1      1      4      A
02      0      1      0     95      T
03     84      8      1      3      A
04     21      1      5     69      T
05     24     24     24     24      n
06     24     24     24     24      n
07     19      1      0     76      T
08     96      0      0      0      A
09      0      0      0     96      T
10     86      3      3      4      A
11     24     24     24     24      n
12     24     24     24     24      n
13      1     64      1     30      y
14     94      0      1      1      A
15      0      0      0     96      T
16     84      1      0     11      A
17     24     24     24     24      n
18     11     11      9     65      t
19      0      0      0     96      T
20      4      0      0     92      T
21     92      0      1      3      A
22      3      1      4     88      T
Binding TFs: 3d1n_I / 3d1n_K (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Binding Sites: 3d1n_C
3d1n_D
			
Publications: Pereira J.H, Kim S.H. Structure of human Brn-5 transcription factor in complex with CRH gene promoter. Journal of structural biology 167:159-65 (2009). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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