DNA Binding Motif

						

			
Accessions: SOHLH2_2 (HT-SELEX2 May2017), MA1560.1 (JASPAR 2024)

			
Names: SOHLH2
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 10
Consensus: ygCACGTGcr
Weblogo: 
PSSM: P0      A      C      G      T
01    230    485    184    313      y
02    172    264   1212    276      g
03     45   1212     29     70      C
04   1212      0     41      0      A
05      0   1212     11      7      C
06     14      0   1212     15      G
07     36     65      0   1212      T
08     41      4   1212      4      G
09    272   1212    172    153      c
10    381    239    369    224      r
Type: Heterodimer
Binding TFs: SOHLH2 (Helix-loop-helix DNA-binding domain)
Q9NX45 (Helix-loop-helix DNA-binding domain)
Q9NX45
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Park M, Lee Y, Jang H, Lee OH, Park SW, Kim JH, Hong K, Song H, Park SP, Park YY, Ko JJ, Choi Y. SOHLH2 is essential for synaptonemal complex formation during spermatogenesis in early postnatal mouse testes. Sci Rep : (2016). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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