DNA Binding Motif
| Accessions: | E2F4_1 (HT-SELEX2 May2017), MA0470.2 (JASPAR 2024) |
| Names: | E2F4 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | HT-SELEX |
| Length: | 14 |
| Consensus: | wTtTGGCGCCawww |
| Weblogo: |  |
| PSSM: | P0 A C G T 01 4332 1036 1772 9141 w 02 3440 926 968 12851 T 03 2541 476 3027 12536 t 04 946 489 1561 13460 T 05 318 2176 13671 20 G 06 10 50 13939 0 G 07 15 13954 2 11 C 08 9 7 13950 25 G 09 0 13939 53 0 C 10 29 13730 3993 577 C 11 12269 4540 1062 2504 a 12 4886 2001 524 8279 w 13 4627 906 846 8792 w 14 5354 2863 2397 6866 w |
| Type: | Heterodimer |
| Binding TFs: | Q16254 (E2F/DP family winged-helix DNA-binding domain) E2F4 (E2F/DP family winged-helix DNA-binding domain) Q16254 |
| Publications: | Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] Rabinovich A, Jin VX, Rabinovich R, Xu X, Farnham PJ. E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites. Genome Res 18:1763-77 (2008). [Pubmed] |
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