DNA Binding Motif

						

			
Accessions: 5wc9_AB (3D-footprint 20231221)

			
Names: Pituitary-specific positive transcription factor 1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Human Pit-1 and 4xCATT DNA complex
Length: 13
Consensus: ATTCATTCATTCA
Weblogo: 
PSSM: P0      A      C      G      T
01     88      0      0      8      A
02      8      0      0     88      T
03      0      0      0     96      T
04      0     96      0      0      C
05     96      0      0      0      A
06      0      0      0     96      T
07      9     14      7     66      T
08      7     73      7      9      C
09     73      2     14      7      A
10      0      0      0     96      T
11      0      0      0     96      T
12      0     96      0      0      C
13     96      0      0      0      A
Type: Heterodimer
Binding TFs: 5wc9_A (Homeobox domain, Pou domain - N-terminal to homeobox domain)
5wc9_B (Homeobox domain, Pou domain - N-terminal to homeobox domain)
Binding Sites: 5wc9_C
5wc9_D
			
Publications: Agarwal S, Cho TY. Biochemical and structural characterization of a novel cooperative binding mode by Pit-1 with CATT repeats in the macrophage migration inhibitory factor promoter. Nucleic Acids Res : (2017). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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