DNA Binding Motif

						

			
Accessions: 3wts_AC (3D-footprint 20231221)

			
Names: Runt-related transcription factor 1
Organisms: Mus musculus, Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of the complex comprised of ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA
Length: 12
Consensus: AGGATGTGGctt
Weblogo: 
PSSM: P0      A      C      G      T
01     89      0      6      1      A
02      0      0     96      0      G
03      0      0     96      0      G
04     89      1      6      0      A
05      0      0      0     96      T
06      0      0     96      0      G
07      0      0      0     96      T
08      0      0     96      0      G
09      0      0     96      0      G
10     12     57     15     12      c
11     12     15     12     57      t
12     12      6     14     64      t
Type: Heterodimer
Binding TFs: 3wts_A (Runt domain)
3wts_C (Ets-domain)
Binding Sites: 3wts_D
3wts_E
			
Publications: Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Uchiyama A, Baba S, Sato K, Yamamoto M, Ogata K. A Novel Allosteric Mechanism on Protein-DNA Interactions underlying the Phosphorylation-Dependent Regulation of Ets1 Target Gene Expressions. Journal of molecular biology 427:1655-69 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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