DNA Binding Motif

Accessions: 5i50_AB (3D-footprint 20231221)
Names: Myc proto-oncogene protein
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of OmoMYC bound to double-stranded DNA
Length: 9
Consensus: CCACGTGAA
01 8 69 11 8 C
02 0 96 0 0 C
03 96 0 0 0 A
04 8 87 0 1 C
05 0 0 96 0 G
06 0 0 0 96 T
07 0 0 96 0 G
08 69 8 11 8 A
09 69 11 8 8 A
Type: Heterodimer
Binding TFs: 5i50_A (Helix-loop-helix DNA-binding domain, Myc leucine zipper domain)
5i50_B (Helix-loop-helix DNA-binding domain, Myc leucine zipper domain)
Binding Sites: 5i50_C
Publications: Jung LA, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M. OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Oncogene : (2016). [Pubmed]

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