DNA Binding Motif

						

			
Accessions: ASCL1_2 (HT-SELEX2 May2017), MA1100.2 (JASPAR 2024)

			
Names: ASCL1
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 10
Consensus: rrCAGCTGcy
Weblogo: 
PSSM: P0      A      C      G      T
01   1267    926   1495    726      r
02   1334    521   3079    354      r
03      0   4413      0     14      C
04   4413    157     60    218      A
05    107   1288   4413    625      G
06    729   4413   1320     20      C
07    118     24    121   4413      T
08     52      0   4413     29      G
09    177   3065    814   1349      c
10    843   1487    889   1194      y
Type: Heterodimer
Binding TFs: ASCL1 (Helix-loop-helix DNA-binding domain)
P50553 (Helix-loop-helix DNA-binding domain)
P50553
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Huang HS, Kubish GM, Redmond TM, Turner DL, Thompson RC, Murphy GG, Uhler MD. Direct transcriptional induction of Gadd45gamma by Ascl1 during neuronal differentiation. Mol Cell Neurosci 44:282-96 (2010). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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