DNA Binding Motif

Accessions: 6edb_B (3D-footprint 20231221)
Names: Sex-determining region Y protein,Cyclic GMP-AMP synthase
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of SRY.hcGAS-21bp dsDNA complex
Length: 4
Consensus: AATg
Weblogo:
PSSM: P0 A C G T
01 92 1 2 1 A
02 74 7 8 7 A
03 6 6 6 78 T
04 13 13 56 14 g
Binding TFs: 6edb_B (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Binding Sites: 6edb_C
6edb_D
Publications: Xie W, Lama L, Adura C, Tomita D, Glickman JF, Tuschl T, Patel DJ. Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Proc Natl Acad Sci U S A 116:11946-11955 (2019). [Pubmed]

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