DNA Binding Motif

						

			
Accessions: 1ic8_AB (3D-footprint 20231221)

			
Names: HEPATOCYTE NUCLEAR FACTOR 1-ALPHA
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT
Length: 17
Consensus: GGTGArTTATtAACCAA
Weblogo: 
PSSM: P0      A      C      G      T
01      0      0     96      0      G
02      0      0     96      0      G
03      0     19      1     76      T
04      0      0     96      0      G
05     88      2      3      3      A
06     38      8     49      1      r
07      0      0      0     96      T
08      0      0      0     96      T
09     91      0      0      5      A
10      0      0      0     96      T
11      3      9     23     61      t
12     96      0      0      0      A
13     96      0      0      0      A
14     15     69      7      5      C
15      0     96      0      0      C
16     74      3     11      8      A
17     79      7      9      1      A
Type: Heterodimer
Binding TFs: 1ic8_A (Homeobox domain, Hepatocyte nuclear factor 1 (HNF-1), N terminus)
1ic8_B (Homeobox domain, Hepatocyte nuclear factor 1 (HNF-1), N terminus)
Binding Sites: 1ic8_E
1ic8_F
			
Publications: Chi Y.I, Frantz J.D, Oh B.C, Hansen L, Dhe-Paganon S, Shoelson S.E. Diabetes mutations delineate an atypical POU domain in HNF-1alpha. Molecular cell 10:1129-37 (2002). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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