DNA Binding Motif
| Accessions: | UP00611A_1 (UniPROBE 20160601) |
| Names: | AN, AN2, Aniridia type II protein, D11S812E, MGC17209, MGDA, Oculorhombin, paired box protein Pax-6, PAX6_REF_R1, WAGR |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Length: | 23 |
| Consensus: | rcrkmwswrTGCAyasrwcmAtr |
| Weblogo: |  |
| PSSM: | P0 A C G T 01 0.41 0.10 0.27 0.22 r 02 0.20 0.52 0.12 0.16 c 03 0.50 0.10 0.30 0.11 r 04 0.21 0.11 0.33 0.34 k 05 0.35 0.42 0.09 0.14 m 06 0.47 0.23 0.05 0.25 w 07 0.06 0.30 0.51 0.14 s 08 0.25 0.01 0.16 0.58 w 09 0.25 0.03 0.61 0.11 r 10 0.05 0.10 0.02 0.83 T 11 0.05 0.01 0.81 0.13 G 12 0.13 0.81 0.01 0.05 C 13 0.83 0.02 0.10 0.05 A 14 0.11 0.61 0.03 0.25 y 15 0.62 0.21 0.02 0.15 a 16 0.14 0.51 0.30 0.06 s 17 0.48 0.08 0.27 0.17 r 18 0.29 0.07 0.09 0.56 w 19 0.25 0.41 0.17 0.18 c 20 0.38 0.33 0.16 0.13 m 21 0.80 0.08 0.09 0.03 A 22 0.20 0.20 0.11 0.48 t 23 0.44 0.10 0.25 0.21 r |
| Binding TFs: | UP00611A (Homeobox domain, 'Paired box' domain) |
| Binding Sites: | AATGTGCA ACTAATTA AGTGCACA ATAATTAG ATGCACAC ATTAATCA ATTAATTA CAATTAAC CTAATTAG GCTAATTA GGGTGCAC GTGCACAC TGCACACA TGTGCACA AATGCACA AATGCGCA ACATTAAC ATGCACAT ATGCGCAT CACATTAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
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