DNA Binding Motif

						

			
Accessions: HLF_full (HumanTF 1.0), MA0043.2 (JASPAR 2024)

			
Names: HLF
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 12
Consensus: yrTTAYrTAAym
Weblogo: 
PSSM: P0      A      C      G      T
01    429    735    379    595      y
02   1149    712    989    118      r
03      7      1      0   2138      T
04      6     38    248   2138      T
05   2138      0    310     21      A
06     15   2138     35    790      Y
07   1758     95   2138     11      r
08     53    680      8   2138      T
09   2138    282      4      6      A
10   2138      0      5      7      A
11    127   1239    280    899      y
12    644    737    360    397      m
Type: Heterodimer
Binding TFs: Q16534 (Basic region leucine zipper)
HLF_full (Basic region leucine zipper)
Q16534
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Hunger S. P., Brown R., Cleary M. L. DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF. Mol. Cell. Biol. 14:5986-5996 (1994). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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