DNA Binding Motif

						

			
Accessions: SP2_2 (HT-SELEX2 May2017), MA0516.2 (JASPAR 2024)

			
Names: SP2
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 17
Consensus: mTAAGyCCCGCCCmCyy
Weblogo: 
PSSM: P0      A      C      G      T
01    256    308    123    106      m
02     53    171     57    608      T
03    613     76      0    180      A
04    753     84     33     67      A
05     54    127    791     43      G
06     34    456      8    327      y
07     14    774      1      0      C
08     16    786     13      8      C
09      4    788     22     12      C
10     82     52    780     45      G
11      0    795      0     18      C
12      5    793     26      7      C
13     23    774      0     27      C
14    402    390     22     17      m
15     22    679      1    101      C
16    109    221      0    503      y
17    150    203     88    352      y
Type: Heterodimer
Binding TFs: Q02086 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
SP2 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Q02086
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Moorefield K. S., Fry S. J., Horowitz J. M. Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells.. J. Biol. Chem. 279:13911-13924 (2004). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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