DNA Binding Motif

						

			
Accessions: HOXA4_2 (HT-SELEX2 May2017), MA1496.1 (JASPAR 2024)

			
Names: HOXA4
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 8
Consensus: rYmATTAr
Weblogo: 
PSSM: P0      A      C      G      T
01   1089    397   1365     94      r
02      0    967      0   2454      Y
03    893   1561    176      0      m
04   2454      0    684      0      A
05      0      0     39   2454      T
06      0    173    171   2454      T
07   2454    146    260      0      A
08    636    593    840    385      r
Type: Heterodimer
Binding TFs: HOXA4 (Homeobox domain)
Q00056 (Homeobox domain)
Q00056
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Wu K, Wolgemuth DJ. Protein product of the somatic-type transcript of the Hoxa-4 (Hox-1. 4) gene binds to homeobox consensus binding sites in its promoter and intron 52:449-62 (J). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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