DNA Binding Motif

						

			
Accessions: GCM1_SPDEF_2_3_4_5 (HumanTF2 1.0)

			
Names: GCM1_SPDEF
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 24
Consensus: rtgsGGGCGGAwgyrydTCCgkkt
Weblogo: 
PSSM: P0      A      C      G      T
01    293    125    250     90      r
02     79     69    119    564      t
03    166     84    484     12      g
04    143    230    163     57      s
05     23     33    441    148      G
06     21     16    588      3      G
07      9     16    588     11      G
08     96    593     24      4      C
09      8      0    593      8      G
10      0      0    594      3      G
11    584     18      3      4      A
12    175     93     14    387      w
13    131    100    525     92      g
14     37    252    136    167      y
15    213     45    244     91      r
16     66    151    134    242      y
17    163     38    189    203      d
18     13     10      8    594      T
19      8    593      8    104      C
20     27    593     10      5      C
21      3    121    510    141      g
22     20    143    486    230      k
23     72    117    237    167      k
24    139     77    131    246      t
Type: Heterodimer
Binding TFs: GCM1_TF1 (GCM motif protein)
SPDEF_TF2 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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