DNA Binding Motif

						

			
Accessions: E2F3_DBD_2 (HumanTF 1.0), MA0469.2 (JASPAR 2024)

			
Names: E2F3
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 18
Consensus: aAAAAkGGCGCCawWTTt
Weblogo: 
PSSM: P0      A      C      G      T
01   1369    284    588    399      a
02   1917     46    565     36      A
03   2202      0     13    234      A
04   2309      0      0    184      A
05   2207      0     46    466      A
06    740      0   1453   1985      k
07     53    520   3761    129      G
08      0      3   3871      0      G
09      0   2490      0      0      C
10      0      3   3985      0      G
11      0   2429      0      0      C
12     97   2411    550     36      C
13   2024    653      0    433      a
14   1399     30     22   2424      w
15   1093     10     12   2921      W
16    437     24     14   2843      T
17     74    429    127   2269      T
18    287    712    355   1504      t
Type: Heterodimer
Binding TFs: E2F3_DBD (E2F/DP family winged-helix DNA-binding domain)
O00716 (E2F/DP family winged-helix DNA-binding domain)
O00716
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Rabinovich A, Jin VX, Rabinovich R, Xu X, Farnham PJ. E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites. Genome Res 18:1763-77 (2008). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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