DNA Binding Motif

						

			
Accessions: MGA_DLX3_1 (HumanTF2 1.0), UN0573.1 (JASPAR 2024)

			
Names: MGA_DLX3, MGA::DLX3
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 12
Consensus: AGGTGwTAATtr
Weblogo: 
PSSM: P0      A      C      G      T
01  33579    215  10447   1653      A
02   2108   1645  33579    691      G
03     34    256  33579     42      G
04      0   4078    389  33579      T
05     25     16  33579    117      G
06  11472   5013   1027  16067      w
07   7318    267   6009  33579      T
08  33579      0   1234    195      A
09  33579    688    219     10      A
10   1477   1007   4664  33579      T
11   3446   2776   8988  24592      t
12  10568    733  23011   4366      r
Type: Heterodimer
Binding TFs: DLX3_TF2 (Homeobox domain)
MGA_TF1 (T-box)
DLX3_Crystal (Homeobox domain)
DLX3_Full (Homeobox domain, Homeobox protein distal-less-like N terminal )
Q8IWI9 (Helix-loop-helix DNA-binding domain, T-box)
Q8IWI9 (Helix-loop-helix DNA-binding domain, T-box)
Q8IWI9
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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