DNA Binding Motif

						

			
Accessions: GCM1_ELK3_1 (HumanTF2 1.0), UN0542.1 (JASPAR 2024)

			
Names: GCM1_ELK3, GCM1::ELK3
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: aCCCGCArCCGGAAGy
Weblogo: 
PSSM: P0      A      C      G      T
01    535     45    176     35      a
02      0    632      0      7      C
03      8    628      0      0      C
04    164    498      0     19      C
05      0     25    627     12      G
06      4    605     14    121      C
07    621      0      0     12      A
08    185    110    247     93      r
09      0    634     54     18      C
10      8    636      3      0      C
11      0     37    635     11      G
12      6     17    641     52      G
13    632     26     21     35      A
14    639     70      1    100      A
15     65     85    566     26      G
16      4    216     42    373      y
Type: Heterodimer
Binding TFs: ELK3_TF2 (Ets-domain)
GCM1_TF1 (GCM motif protein)
Q9NP62 (GCM motif protein)
Q9NP62
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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