DNA Binding Motif

						

			
Accessions: E2F8_DBD (HumanTF 1.0), MA0865.1 (JASPAR 2024)

			
Names: E2F8
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4; < 100 counts, HT-SELEX
Length: 12
Consensus: TTTCCCGCCAAA
Weblogo: 
PSSM: P0      A      C      G      T
01      3      3      1     87      T
02      0      3      0     90      T
03      0      0      1     92      T
04      0     98      0      1      C
05      0     96      0      3      C
06      0     97      1      0      C
07      4      7    119      0      G
08      0     96      0      1      C
09      2     93      4      0      C
10     80      1      3      1      A
11     83      0      0      0      A
12     79      2      1      4      A
Type: Heterodimer
Binding TFs: E2F8_DBD (E2F/DP family winged-helix DNA-binding domain)
A0AVK6 (E2F/DP family winged-helix DNA-binding domain)
A0AVK6
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Rabinovich A, Jin VX, Rabinovich R, Xu X, Farnham PJ. E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites. Genome Res 18:1763-77 (2008). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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