DNA Binding Motif

						

			
Accessions: 4l0z_AB (3D-footprint 20231221)

			
Names: Runt-related transcription factor 1
Organisms: Mus musculus, Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 2)
Length: 12
Consensus: AAgCCACATCCT
Weblogo: 
PSSM: P0      A      C      G      T
01     84      0      7      5      A
02     73     11      0     12      A
03     16      5     64     11      g
04      0     96      0      0      C
05      0     96      0      0      C
06     96      0      0      0      A
07      0     96      0      0      C
08     75      5     11      5      A
09      0      0      0     96      T
10      0     96      0      0      C
11      0     96      0      0      C
12      5      5      5     81      T
Type: Heterodimer
Binding TFs: 4l0z_A (Runt domain)
4l0z_B (Ets-domain)
Binding Sites: 4l0z_C
4l0z_D
			
Publications: Shrivastava T, Mino K, Babayeva N.D, Baranovskaya O.I, Rizzino A, Tahirov T.H. Structural basis of Ets1 activation by Runx1. Leukemia 28:2040-8 (2014). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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