DNA Binding Motif

						

			
Accessions: PAX8_2 (HT-SELEX2 May2017), UN0133.1 (JASPAR 2024)

			
Names: PAX8
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 20
Consensus: ycGTCACGCwYsrsyrmsym
Weblogo: 
PSSM: P0      A      C      G      T
01   1290   2872   1493   2132      y
02    674   5749   2039    786      c
03     41     18   7788    461      G
04    888   1164     20   7788      T
05     40   7788     31   1642      C
06   7788     17    148     95      A
07     17   7788      4   1283      C
08    156     10   7788      0      G
09      9   7788   2490      2      C
10   3902    979    489   3886      w
11    137   3301      2   7788      Y
12     15   3253   4534     35      s
13   7788     43   3680     16      r
14   1487   2791   2034   1475      s
15    392   2906    266   4882      y
16   3092     54   7788    552      r
17   2273   3758   1701     56      m
18   1733   2028   2279   1747      s
19    251   4595    611   3193      y
20   2265   2279   1407   1837      m
Type: Heterodimer
Binding TFs: PAX8 / Q06710 ('Paired box' domain, Paired-box protein 2 C terminal)
Q06710
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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