DNA Binding Motif

						

			
Accessions: 6qhd_AB (3D-footprint 20231221)

			
Names: Signal transducer and activator of transcription 3
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA
Length: 9
Consensus: TTACsGGAA
Weblogo: 
PSSM: P0      A      C      G      T
01      8      0      8     80      T
02      0      0      0     96      T
03     96      0      0      0      A
04      0     96      0      0      C
05     10     52     26      8      s
06      0      0     96      0      G
07      0      0     79     17      G
08     96      0      0      0      A
09     71     17      0      8      A
Type: Heterodimer
Binding TFs: 6qhd_A (SH2 domain, STAT protein, all-alpha domain, STAT protein, DNA binding domain)
6qhd_B (SH2 domain, STAT protein, all-alpha domain, STAT protein, DNA binding domain)
Binding Sites: 6qhd_C
6qhd_D
			
Publications: Belo Y, Mielko Z, Nudelman H, Afek A, Ben-David O, Shahar A, Zarivach R, Gordan R, Arbely E. Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine. Biochim Biophys Acta Gen Subj 1863:1343-1350 (2019). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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