DNA Binding Motif

Accessions: 6ama_ABCDGHKLOPY (3D-footprint 20231221)
Names: Putative DNA-binding protein
Organisms: strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745, Streptomyces venezuelae
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of S. coelicolor/S. venezuelae BldC-smeA-ssfA complex to 3.09 Angstrom
Length: 96
Consensus: TACCCGnnnTACCCnAnnTACCCnAnnTACCCnnnTTACCCGnnTTACCCGnnnTACCCGnnnTACCCGnnTTACCCGnnnTACCCnnnTTACCCG
Weblogo:
PSSM: P0 A C G T
01 0 0 0 96 T
02 96 0 0 0 A
03 1 94 0 1 C
04 0 96 0 0 C
05 0 96 0 0 C
06 0 0 96 0 G
07 24 24 24 24 n
08 24 24 24 24 n
09 24 24 24 24 n
10 0 0 0 96 T
11 96 0 0 0 A
12 0 96 0 0 C
13 0 96 0 0 C
14 0 96 0 0 C
15 24 24 24 24 n
16 90 0 1 5 A
17 24 24 24 24 n
18 24 24 24 24 n
19 0 0 0 96 T
20 96 0 0 0 A
21 0 96 0 0 C
22 0 96 0 0 C
23 0 96 0 0 C
24 24 24 24 24 n
25 90 1 4 1 A
26 24 24 24 24 n
27 24 24 24 24 n
28 0 0 0 96 T
29 92 1 1 2 A
30 0 96 0 0 C
31 0 96 0 0 C
32 0 96 0 0 C
33 24 24 24 24 n
34 24 24 24 24 n
35 24 24 24 24 n
36 6 7 5 78 T
37 0 0 0 96 T
38 96 0 0 0 A
39 0 96 0 0 C
40 0 96 0 0 C
41 0 96 0 0 C
42 1 0 92 3 G
43 24 24 24 24 n
44 24 24 24 24 n
45 1 1 1 93 T
46 0 0 0 96 T
47 96 0 0 0 A
48 0 96 0 0 C
49 4 90 1 1 C
50 0 96 0 0 C
51 0 0 96 0 G
52 24 24 24 24 n
53 24 24 24 24 n
54 24 24 24 24 n
55 0 0 0 96 T
56 96 0 0 0 A
57 0 95 0 1 C
58 0 96 0 0 C
59 0 96 0 0 C
60 5 0 88 3 G
61 24 24 24 24 n
62 24 24 24 24 n
63 24 24 24 24 n
64 0 0 0 96 T
65 96 0 0 0 A
66 0 96 0 0 C
67 0 96 0 0 C
68 0 96 0 0 C
69 8 0 88 0 G
70 24 24 24 24 n
71 24 24 24 24 n
72 6 3 7 80 T
73 0 0 0 96 T
74 96 0 0 0 A
75 0 96 0 0 C
76 0 96 0 0 C
77 0 96 0 0 C
78 1 4 90 1 G
79 24 24 24 24 n
80 24 24 24 24 n
81 24 24 24 24 n
82 0 2 0 94 T
83 96 0 0 0 A
84 0 96 0 0 C
85 0 96 0 0 C
86 0 96 0 0 C
87 24 24 24 24 n
88 24 24 24 24 n
89 24 24 24 24 n
90 5 5 7 79 T
91 0 0 0 96 T
92 86 7 2 1 A
93 0 94 2 0 C
94 0 96 0 0 C
95 0 94 0 2 C
96 0 0 96 0 G
Type: Heterodimer
Binding TFs: 6ama_A / 6ama_C / 6ama_D / 6ama_G / 6ama_K / 6ama_L (MerR family regulatory protein, Helix-turn-helix domain, MerR HTH family regulatory protein)
6ama_B (MerR family regulatory protein, Helix-turn-helix domain, MerR HTH family regulatory protein)
6ama_H / 6ama_O (MerR family regulatory protein, Helix-turn-helix domain, MerR HTH family regulatory protein)
6ama_P (MerR family regulatory protein, Helix-turn-helix domain, MerR HTH family regulatory protein)
6ama_Y (MerR family regulatory protein, Helix-turn-helix domain, MerR HTH family regulatory protein)
Binding Sites: 6ama_N
6ama_R
Publications: Schumacher MA, den Hengst CD, Bush MJ, Le TBK, Tran NT, Chandra G, Zeng W, Travis B, Brennan RG, Buttner MJ. The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development. Nat Commun 9:1139 (2018). [Pubmed]

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