DNA Binding Motif

						

			
Accessions: 6ama_ABCDGHKLOPY (3D-footprint 20231221)

			
Names: Putative DNA-binding protein
Organisms: strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745, Streptomyces venezuelae
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Structure of S. coelicolor/S. venezuelae BldC-smeA-ssfA complex to 3.09 Angstrom
Length: 96
Consensus: TACCCGnnnTACCCnAnnTACCCnAnnTACCCnnnTTACCCGnnTTACCCGnnnTACCCGnnnTACCCGnnTTACCCGnnnTACCCnnnTTACCCG
Weblogo: 
PSSM: P0      A      C      G      T
01      0      0      0     96      T
02     96      0      0      0      A
03      1     94      0      1      C
04      0     96      0      0      C
05      0     96      0      0      C
06      0      0     96      0      G
07     24     24     24     24      n
08     24     24     24     24      n
09     24     24     24     24      n
10      0      0      0     96      T
11     96      0      0      0      A
12      0     96      0      0      C
13      0     96      0      0      C
14      0     96      0      0      C
15     24     24     24     24      n
16     90      0      1      5      A
17     24     24     24     24      n
18     24     24     24     24      n
19      0      0      0     96      T
20     96      0      0      0      A
21      0     96      0      0      C
22      0     96      0      0      C
23      0     96      0      0      C
24     24     24     24     24      n
25     90      1      4      1      A
26     24     24     24     24      n
27     24     24     24     24      n
28      0      0      0     96      T
29     92      1      1      2      A
30      0     96      0      0      C
31      0     96      0      0      C
32      0     96      0      0      C
33     24     24     24     24      n
34     24     24     24     24      n
35     24     24     24     24      n
36      6      7      5     78      T
37      0      0      0     96      T
38     96      0      0      0      A
39      0     96      0      0      C
40      0     96      0      0      C
41      0     96      0      0      C
42      1      0     92      3      G
43     24     24     24     24      n
44     24     24     24     24      n
45      1      1      1     93      T
46      0      0      0     96      T
47     96      0      0      0      A
48      0     96      0      0      C
49      4     90      1      1      C
50      0     96      0      0      C
51      0      0     96      0      G
52     24     24     24     24      n
53     24     24     24     24      n
54     24     24     24     24      n
55      0      0      0     96      T
56     96      0      0      0      A
57      0     95      0      1      C
58      0     96      0      0      C
59      0     96      0      0      C
60      5      0     88      3      G
61     24     24     24     24      n
62     24     24     24     24      n
63     24     24     24     24      n
64      0      0      0     96      T
65     96      0      0      0      A
66      0     96      0      0      C
67      0     96      0      0      C
68      0     96      0      0      C
69      8      0     88      0      G
70     24     24     24     24      n
71     24     24     24     24      n
72      6      3      7     80      T
73      0      0      0     96      T
74     96      0      0      0      A
75      0     96      0      0      C
76      0     96      0      0      C
77      0     96      0      0      C
78      1      4     90      1      G
79     24     24     24     24      n
80     24     24     24     24      n
81     24     24     24     24      n
82      0      2      0     94      T
83     96      0      0      0      A
84      0     96      0      0      C
85      0     96      0      0      C
86      0     96      0      0      C
87     24     24     24     24      n
88     24     24     24     24      n
89     24     24     24     24      n
90      5      5      7     79      T
91      0      0      0     96      T
92     86      7      2      1      A
93      0     94      2      0      C
94      0     96      0      0      C
95      0     94      0      2      C
96      0      0     96      0      G
Type: Heterodimer
Binding TFs: 6ama_A / 6ama_C / 6ama_D / 6ama_G / 6ama_K / 6ama_L (MerR family regulatory protein, Helix-turn-helix domain, MerR HTH family regulatory protein)
6ama_B (MerR family regulatory protein, Helix-turn-helix domain, MerR HTH family regulatory protein)
6ama_H / 6ama_O (MerR family regulatory protein, Helix-turn-helix domain, MerR HTH family regulatory protein)
6ama_P (MerR family regulatory protein, Helix-turn-helix domain, MerR HTH family regulatory protein)
6ama_Y (MerR family regulatory protein, Helix-turn-helix domain, MerR HTH family regulatory protein)
Binding Sites: 6ama_N
6ama_R
			
Publications: Schumacher MA, den Hengst CD, Bush MJ, Le TBK, Tran NT, Chandra G, Zeng W, Travis B, Brennan RG, Buttner MJ. The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development. Nat Commun 9:1139 (2018). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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