DNA Binding Motif

						

			
Accessions: CLOCK_FIGLA_1 (HumanTF2 1.0)

			
Names: CLOCK_FIGLA
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 23
Consensus: sCAssTGkyvbywaraCRCRTGy
Weblogo: 
PSSM: P0      A      C      G      T
01   2177   3950   2560   1210      s
02    656   9897     70     43      C
03   9897    119    547    358      A
04     89   4692   5204    842      s
05    403   5969   3928    177      s
06    116    308     16   9897      T
07     44      6   9897    336      G
08    611   2580   5230   4667      k
09   1873   3288   1776   2960      y
10   3125   2899   2630   1242      v
11   1670   2903   2755   2570      b
12   1937   3021   2446   2492      y
13   3283   2248   1695   2670      w
14   4095   2192   1917   1693      a
15   2535   1593   3731   2038      r
16   4370   2238   2432    857      a
17   1360   9897     47      5      C
18   9897    163   4179    176      R
19    121   9897    499   1519      C
20   3460    355   9897     16      R
21    426   2788    772   9897      T
22    226     23   9897   1973      G
23   1159   2514   1387   4837      y
Type: Heterodimer
Binding TFs: CLOCK_TF1 / CLOCK_TF2 (Helix-loop-helix DNA-binding domain)
FIGLA_TF2 (Helix-loop-helix DNA-binding domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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