DNA Binding Motif

						

			
Accessions: LEF1_DBD (HumanTF 1.0), MA0768.1 (JASPAR 2024)

			
Names: LEF1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 4, HT-SELEX
Length: 15
Consensus: aAAGATCAAAGgrww
Weblogo: 
PSSM: P0      A      C      G      T
01    601    139    215    138      a
02    655     26    207     63      A
03    697      7     34     14      A
04      5    242   1053      3      G
05    699      0      4     15      A
06      9      3      0    898      T
07     14    935     49      5      C
08    711      0      0      4      A
09    709      0      4      0      A
10    712      0     13      4      A
11     33     24   1068      0      G
12    197    184    851    124      g
13    309    164    559    121      r
14    367     63     88    372      w
15    366     95     77    422      w
Type: Heterodimer
Binding TFs: LEF1_DBD (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Q9UJU2 (HMG (high mobility group) box, N-terminal CTNNB1 binding, Domain of unknown function (DUF1898))
Q9UJU2
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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