DNA Binding Motif

						

			
Accessions: 5ego_AB (3D-footprint 20231221)

			
Names: Homeobox protein Meis1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: HOXB13-MEIS1 heterodimer bound to methylated DNA
Length: 14
Consensus: TGACAgnTTTAnna
Weblogo: 
PSSM: P0      A      C      G      T
01      0      0     12     84      T
02      0      0     96      0      G
03     96      0      0      0      A
04      0     96      0      0      C
05     96      0      0      0      A
06     12     12     60     12      g
07     24     24     24     24      n
08      0      0      0     96      T
09      0      0      0     96      T
10      0      0      0     96      T
11     96      0      0      0      A
12     24     24     24     24      n
13     24     24     24     24      n
14     60     12     12     12      a
Type: Heterodimer
Binding TFs: 5ego_A (Homeobox domain, Homeobox KN domain)
5ego_B (Homeobox domain)
Binding Sites: 5ego_D
5ego_E
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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