DNA Binding Motif

						

			
Accessions: ZNF343_2 (HT-SELEX2 May2017), UN0183.1 (JASPAR 2024), MA1711.1 (JASPAR 2024)

			
Names: ZNF343
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: HT-SELEX
Length: 17
Consensus: cCGCTTCmCcrCGGymv
Weblogo: 
PSSM: P0      A      C      G      T
01  10105  24859  10803   2940      c
02   4185  37120   1986   9478      C
03   4153    151  47061    489      G
04      0  48708      0      8      C
05     19     27      0  48711      T
06      0     34      4  48706      T
07      0  48704      0      0      C
08  33687  21143    860   3644      m
09    596  46517   2241   2021      C
10   3426  40351   9030   6764      c
11  18171   3888  15622  11027      r
12    878  47833    237   4238      C
13   1177    394  48313    354      G
14   2191   1946  46961   1520      G
15   1464  34074   1258  13952      y
16  30490  16736   2040   3551      m
17  12611  14914  14645   6537      v
Type: Heterodimer
Binding TFs: ZNF343 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger)
Q6P1L6 (Zinc finger, C2H2 type, KRAB box, Zinc-finger double domain, C2H2-type zinc finger, C2H2-type zinc finger)
Q6P1L6
			
Publications: Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]


Imbeault M, Helleboid PY, Trono D. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Nature 543:550-554 (2017). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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