DNA Binding Motif

						

			
Accessions: 4hn6_AB (3D-footprint 20231221)

			
Names: Glucocorticoid receptor
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: GR DNA Binding Domain R460D/D462R - TSLP nGRE Complex
Length: 14
Consensus: CTcTnCcnnnnGCG
Weblogo: 
PSSM: P0      A      C      G      T
01      2     76      2     16      C
02      2      2      2     90      T
03     11     54     15     16      c
04      3      2      2     89      T
05     24     24     24     24      n
06      0     91      3      2      C
07     15     54     16     11      c
08     24     24     24     24      n
09     24     24     24     24      n
10     24     24     24     24      n
11     24     24     24     24      n
12      3      2     89      2      G
13      0     96      0      0      C
14      0      0     96      0      G
Binding TFs: 4hn6_A / 4hn6_B (Zinc finger, C4 type (two domains))
Binding Sites: 4hn6_C
4hn6_D
			
Publications: Hudson W.H, Youn C, Ortlund E.A. The structural basis of direct glucocorticoid-mediated transrepression. Nature structural & molecular biology 20:53-8 (2013). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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