DNA Binding Motif
| Accessions: | NHLH2_2 (HT-SELEX2 May2017), MA1529.1 (JASPAR 2024) |
| Names: | NHLH2 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | HT-SELEX |
| Length: | 18 |
| Consensus: | ggGyMGCAGCTGCGyCmc |
| Weblogo: |  |
| PSSM: | P0 A C G T 01 4834 2655 9732 4143 g 02 4312 2219 13903 5198 g 03 3741 1065 18450 2763 G 04 4921 6141 4908 5394 y 05 5603 15451 671 151 M 06 2378 2324 18930 2634 G 07 2 21359 2 5 C 08 21364 0 26 1 A 09 6 2459 20096 1054 G 10 525 20268 2266 0 C 11 0 14 3 21358 T 12 0 2 21363 0 G 13 693 20611 275 1230 C 14 210 204 20977 740 G 15 1184 7207 1520 13503 y 16 3766 18351 1183 2533 C 17 6392 13462 1579 3330 m 18 3601 11271 2264 4228 c |
| Type: | Heterodimer |
| Binding TFs: | NHLH2 / Q02577 (Helix-loop-helix DNA-binding domain) Q02577 |
| Publications: | Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] Weirauch MT, Cote A, Norel R, Annala M, Zhao Y, Riley TR, Saez-Rodriguez J, Cokelaer T, Vedenko A, Talukder S; DREAM5 Consortium, Bussemaker HJ, Morris QD, Bulyk ML, Stolovitzky G, Hughes TR. Evaluation of methods for modeling transcription factor sequence specificity. Nat Biotechnol 31:126-34 (2013). [Pubmed] |
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