DNA Binding Motif

						

			
Accessions: E2F1_HES7_2 (HumanTF2 1.0), UN0490.1 (JASPAR 2024)

			
Names: E2F1_HES7, E2F1::HES7
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 21
Consensus: grCrCGTGsyrywaGGCGCsm
Weblogo: 
PSSM: P0      A      C      G      T
01    159    234    547     28      g
02    239     90    542     31      r
03     74    781     14     32      C
04    426     18    355     12      r
05     23    781      9     28      C
06     16     26    781      8      G
07     41     60     27    721      T
08     22     20    781     20      G
09     49    444    337    115      s
10     48    396     71    385      y
11    203     56    346    176      r
12    150    268    100    263      y
13    388     32     74    287      w
14    377    141    100    163      a
15     85    138    644      0      G
16     53     16    781      2      G
17      6    781     17     19      C
18     68     28    781      9      G
19     23    781    107     88      C
20      8    462    320    164      s
21    237    376     55    114      m
Type: Heterodimer
Binding TFs: E2F1_TF1 (E2F/DP family winged-helix DNA-binding domain)
HES7_TF2 (Helix-loop-helix DNA-binding domain)
Q9BYE0 (Helix-loop-helix DNA-binding domain)
Q9BYE0
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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