DNA Binding Motif

Accessions: 3cbb_A (3D-footprint 20231221)
Names: Hepatocyte Nuclear Factor 4-alpha, DNA binding domain
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of Hepatocyte Nuclear Factor 4alpha in complex with DNA: Diabetes Gene Product
Length: 5
Consensus: GTCCA
01 0 0 96 0 G
02 9 11 9 67 T
03 9 69 9 9 C
04 0 96 0 0 C
05 67 11 9 9 A
Binding TFs: 3cbb_A (Zinc finger, C4 type (two domains))
Binding Sites: 3cbb_C
Publications: Lu P, Rha G.B, Melikishvili M, Wu G, Adkins B.C, Fried M.G, Chi Y.I. Structural basis of natural promoter recognition by a unique nuclear receptor, HNF4alpha. Diabetes gene product. The Journal of biological chemistry 283:33685-97 (2008). [Pubmed]

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