DNA Binding Motif

						

			
Accessions: E2F1_NHLH1 (HumanTF2 1.0)

			
Names: E2F1_NHLH1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 26
Consensus: sGCGCswyrmygkkgcmGCAGCTGCk
Weblogo: 
PSSM: P0      A      C      G      T
01     63    421    458      0      s
02      0     30    879      3      G
03      7    879      4      0      C
04      7     41    879      5      G
05      2    879     12    124      C
06     88    879    836     77      s
07    360    103    116    300      w
08    129    308    118    325      y
09    267    189    227    195      r
10    338    241    103    197      m
11    100    349    194    236      y
12    187    181    405    105      g
13    188     88    322    281      k
14    138     74    361    306      k
15    186     23    588     82      g
16    170    345    218    147      c
17    255    452     94     78      m
18    110     27    648     94      G
19      9    879      0      7      C
20    879     18      4     54      A
21     31    123    879     22      G
22      8    879     30     10      C
23     71     20     31    879      T
24     13     11    879      9      G
25    100    624    147      8      C
26     21    172    382    303      k
Type: Heterodimer
Binding TFs: E2F1_TF1 (E2F/DP family winged-helix DNA-binding domain)
NHLH1_TF2 (Helix-loop-helix DNA-binding domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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