DNA Binding Motif

						

			
Accessions: 5flv_I (3D-footprint 20231221)

			
Names: HOMEOBOX PROTEIN NKX-2.5, T-BOX TRANSCRIPTION FACTOR TBX5
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of NKX2-5 and TBX5 bound to the Nppa promoter region
Length: 14
Consensus: CACnnTTGAAGnGg
Weblogo: 
PSSM: P0      A      C      G      T
01      0     96      0      0      C
02     79      7      5      5      A
03     11     69      5     11      C
04     24     24     24     24      n
05     24     24     24     24      n
06      5      2      5     84      T
07      0      0      0     96      T
08      0      0     96      0      G
09     79      7      5      5      A
10     96      0      0      0      A
11      0      0     96      0      G
12     24     24     24     24      n
13      0      0     96      0      G
14     11     11     63     11      g
Binding TFs: 5flv_I (Homeobox domain, T-box)
Binding Sites: 5flv_J
5flv_K
			
Publications: Luna-Zurita L, Stirnimann CU, Glatt S, Kaynak BL, Thomas S, Baudin F, Samee MA, He D, Small EM, Mileikovsky M, Nagy A, Holloway AK, Pollard KS, Müller CW, Bruneau BG. Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis. Cell 164:999-1014 (2016). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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