DNA Binding Motif

						

			
Accessions: 6fqq_AB (3D-footprint 20231221)

			
Names: Homeobox protein TGIF1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal structure of TALE homeobox domain transcription factor TGIF1 double alanine mutant bound to its consensus DNA
Length: 12
Consensus: tGACAgnTGTCA
Weblogo: 
PSSM: P0      A      C      G      T
01      9     13     13     61      t
02      0      0     96      0      G
03     96      0      0      0      A
04      0     96      0      0      C
05     71      6     13      6      A
06     20     16     54      6      g
07     24     24     24     24      n
08      0      0      0     96      T
09      0      0     96      0      G
10      0      7      0     89      T
11      0     96      0      0      C
12     96      0      0      0      A
Type: Heterodimer
Binding TFs: 6fqq_A (Homeobox domain, Homeobox KN domain)
6fqq_B (Homeobox domain, Homeobox KN domain)
Binding Sites: 6fqq_L / 6fqq_M
			
Publications: Guca E, Suñol D, Ruiz L, Konkol A, Cordero J, Torner C, Aragon E, Martin-Malpartida P, Riera A, Macias MJ. TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling. Nucleic Acids Res 46:9220-9235 (2018). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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