DNA Binding Motif

						

			
Accessions: 1zlk_AB (3D-footprint 20231221)

			
Names: Dormancy Survival Regulator
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR C-terminal Domain-DNA Complex
Length: 15
Consensus: AGGGACTnnAGTCCC
Weblogo: 
PSSM: P0      A      C      G      T
01     73      7      7      9      A
02      0      0     96      0      G
03      0      0     96      0      G
04      0      0     96      0      G
05     96      0      0      0      A
06      0     96      0      0      C
07      7      9      7     73      T
08     24     24     24     24      n
09     24     24     24     24      n
10     73      9      7      7      A
11      0      0     96      0      G
12      0      0      0     96      T
13      0     96      0      0      C
14      7     75      7      7      C
15      0     96      0      0      C
Binding TFs: 1zlk_A / 1zlk_B (Bacterial regulatory proteins, luxR family, Sigma-70, region 4)
Binding Sites: 1zlk_C
1zlk_D
			
Publications: Wisedchaisri G, Wu M, Rice A.E, Roberts D.M, Sherman D.R, Hol W.G. Structures of Mycobacterium tuberculosis DosR and DosR-DNA complex involved in gene activation during adaptation to hypoxic latency. Journal of molecular biology 354:630-41 (2005). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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