DNA Binding Motif

						

			
Accessions: ALX4_TBX21_2 (HumanTF2 1.0), UN0485.1 (JASPAR 2024)

			
Names: ALX4_TBX21, ALX4::TBX21
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 12
Consensus: AGGTGytAATwa
Weblogo: 
PSSM: P0      A      C      G      T
01  12970      4   2050    837      A
02   1639   1616  15021    891      G
03      8    123  15021    179      G
04      0   2028     20  15021      T
05      0      0  15021      0      G
06   1332   7244    418   7777      y
07   2508   1598   3375  15021      t
08  15021      0    492      3      A
09  15021    872      8      6      A
10    753    673    823  15021      T
11   6560   1485   1350   8461      w
12  10975   2008   4045   2219      a
Type: Heterodimer
Binding TFs: ALX4_TF2 (Homeobox domain)
TBX21_TF2 (T-box)
ALX4_TF1 (Homeobox domain)
Q9UL17 (T-box)
Q9UL17
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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