DNA Binding Motif

						

			
Accessions: 6vvy_CDFJM (3D-footprint 20231221)

			
Names: RNA polymerase sigma factor SigA
Organisms: Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Mycobacterium tuberculosis WT RNAP transcription open promoter complex with Sorangicin
Length: 41
Consensus: AACnCTGCCAGTCTAAnnnAnnnnnnnnnnnnnnGTCAAGA
Weblogo: 
PSSM: P0      A      C      G      T
01     96      0      0      0      A
02     96      0      0      0      A
03      0     96      0      0      C
04     24     24     24     24      n
05      7     73      7      9      C
06      0      0      0     96      T
07      0      0     96      0      G
08      0     96      0      0      C
09      0     96      0      0      C
10     96      0      0      0      A
11      0      0     96      0      G
12      7      9      7     73      T
13      0     96      0      0      C
14      0      0      0     96      T
15     96      0      0      0      A
16     96      0      0      0      A
17     24     24     24     24      n
18     24     24     24     24      n
19     24     24     24     24      n
20     96      0      0      0      A
21     24     24     24     24      n
22     24     24     24     24      n
23     24     24     24     24      n
24     24     24     24     24      n
25     24     24     24     24      n
26     24     24     24     24      n
27     24     24     24     24      n
28     24     24     24     24      n
29     24     24     24     24      n
30     24     24     24     24      n
31     24     24     24     24      n
32     24     24     24     24      n
33     24     24     24     24      n
34     24     24     24     24      n
35      9      7     73      7      G
36      0      0      0     96      T
37      0     96      0      0      C
38     96      0      0      0      A
39     96      0      0      0      A
40      0      0     96      0      G
41     73      7      7      9      A
Type: Heterodimer
Binding TFs: 6vvy_F (Sigma-70 factor, region 1.2, Sigma-70 region 3, Sigma-70 region 2 , Sigma-70, region 4)
6vvy_M (CarD-like/TRCF domain)
Binding Sites: 6vvy_O
6vvy_P
			
Publications: Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc Natl Acad Sci U S A 117:30423-30432 (2020). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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