DNA Binding Motif

						

			
Accessions: RFX5_DBD_1 (HumanTF 1.0), MA0510.2 (JASPAR 2024)

			
Names: RFX5
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 2, HT-SELEX
Length: 16
Consensus: sGTTrCYATGGyAACs
Weblogo: 
PSSM: P0      A      C      G      T
01    277   1075    790    490      s
02     90      0   2819      9      G
03      4     33     15   2902      T
04     47     98     10   2842      T
05    821     81   1675    142      r
06      3   2378     38     69      C
07      1   2118      7    725      Y
08   2146     42     47    188      A
09    144     56     22   2872      T
10    760     11   2266      8      G
11    143     48   2664      0      G
12    139   1613     61    882      y
13   2166     10     99     46      A
14   2206     21     16      9      A
15     26   2379     12     67      C
16    462    890    905    286      s
Type: Heterodimer
Binding TFs: RFX5_DBD (RFX DNA-binding domain, Poxvirus D5 protein-like)
P48382 (RFX DNA-binding domain)
P48382
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Emery P., Strubin M., Hofmann K., Bucher P., Mach B., Reith W. A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity. Mol. Cell. Biol. 16:4486-4494 (1996). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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