DNA Binding Motif

Accessions: UP00051A_2 (UniPROBE 20160601)
Names: Sox-8, Sox8, SRY-box containing gene 8, Transcription factor SOX-8
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 14
Consensus: acATTCAtgamass
Weblogo:
PSSM: P0 A C G T
01 0.41 0.17 0.21 0.21 a
02 0.17 0.50 0.13 0.20 c
03 0.85 0.04 0.02 0.09 A
04 0.02 0.03 0.03 0.92 T
05 0.03 0.02 0.02 0.93 T
06 0.06 0.81 0.03 0.10 C
07 0.91 0.02 0.06 0.01 A
08 0.05 0.12 0.16 0.67 t
09 0.23 0.09 0.57 0.11 g
10 0.42 0.19 0.16 0.23 a
11 0.26 0.34 0.20 0.20 m
12 0.52 0.20 0.11 0.16 a
13 0.20 0.29 0.28 0.24 s
14 0.23 0.28 0.37 0.13 s
Binding TFs: UP00051A (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Binding Sites: ATTATAAT
AAAACAAT
AAACAATT
AACAATAG
AACAATTG
AAGACAAT
AATGAATT
AATTGTTA
AATTGTTC
ACAACAAT
ACAATTGA
ACAATTGT
AGAACAAT
ATGAATTA
ATGAATTG
ATTCATTC
ATTGTTAA
ATTGTTCG
ATTGTTTC
GAACAATA
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]

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