DNA Binding Motif

Accessions: 6wc2_IJN (3D-footprint 20231221)
Names: MEF2 Chimera,Myocyte-specific enhancer factor 2B,Myocyte-specific enhancer factor 2A
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex
Length: 17
Consensus: CTAnnnnnnGAAAAnGC
Weblogo:
PSSM: P0 A C G T
01 12 72 6 6 C
02 0 0 0 96 T
03 70 6 12 8 A
04 24 24 24 24 n
05 24 24 24 24 n
06 24 24 24 24 n
07 24 24 24 24 n
08 24 24 24 24 n
09 24 24 24 24 n
10 0 0 96 0 G
11 96 0 0 0 A
12 96 0 0 0 A
13 96 0 0 0 A
14 84 0 12 0 A
15 24 24 24 24 n
16 6 6 72 12 G
17 1 83 6 6 C
Type: Heterodimer
Binding TFs: 6wc2_N (Homeobox domain)
6wc2_I (SRF-type transcription factor (DNA-binding and dimerisation domain))
6wc2_J (SRF-type transcription factor (DNA-binding and dimerisation domain))
Binding Sites: 6wc2_E
6wc2_F
Publications: Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed]

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