DNA Binding Motif

						

			
Accessions: 6wc2_IJN (3D-footprint 20231221)

			
Names: MEF2 Chimera,Myocyte-specific enhancer factor 2B,Myocyte-specific enhancer factor 2A
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex
Length: 17
Consensus: CTAnnnnnnGAAAAnGC
Weblogo: 
PSSM: P0      A      C      G      T
01     12     72      6      6      C
02      0      0      0     96      T
03     70      6     12      8      A
04     24     24     24     24      n
05     24     24     24     24      n
06     24     24     24     24      n
07     24     24     24     24      n
08     24     24     24     24      n
09     24     24     24     24      n
10      0      0     96      0      G
11     96      0      0      0      A
12     96      0      0      0      A
13     96      0      0      0      A
14     84      0     12      0      A
15     24     24     24     24      n
16      6      6     72     12      G
17      1     83      6      6      C
Type: Heterodimer
Binding TFs: 6wc2_N (Homeobox domain)
6wc2_I (SRF-type transcription factor (DNA-binding and dimerisation domain))
6wc2_J (SRF-type transcription factor (DNA-binding and dimerisation domain))
Binding Sites: 6wc2_E
6wc2_F
			
Publications: Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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