DNA Binding Motif

						

			
Accessions: 3cbb_AB (3D-footprint 20231221)

			
Names: Hepatocyte Nuclear Factor 4-alpha, DNA binding domain
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of Hepatocyte Nuclear Factor 4alpha in complex with DNA: Diabetes Gene Product
Length: 12
Consensus: GTCCAnGGTTCA
Weblogo: 
PSSM: P0      A      C      G      T
01      0      0     96      0      G
02      4     12      4     76      T
03      4     84      4      4      C
04      0     96      0      0      C
05     84      4      4      4      A
06     24     24     24     24      n
07     12      4     76      4      G
08      0      0     96      0      G
09      4      4      0     88      T
10      4     12      4     76      T
11      0     96      0      0      C
12     84      4      4      4      A
Type: Heterodimer
Binding TFs: 3cbb_A (Zinc finger, C4 type (two domains))
3cbb_B (Zinc finger, C4 type (two domains))
Binding Sites: 3cbb_C
3cbb_D
			
Publications: Lu P, Rha G.B, Melikishvili M, Wu G, Adkins B.C, Fried M.G, Chi Y.I. Structural basis of natural promoter recognition by a unique nuclear receptor, HNF4alpha. Diabetes gene product. The Journal of biological chemistry 283:33685-97 (2008). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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